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Cinnarizine Cinnarizine is a drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness Is cinnarizine a drug? link springer com article 10 1007 s40261-019-00858-6Cinnarizine Instructions for use: 1 Release form and composition 2 Indications for use 3 Contraindications 4 Method of application and dosage 5 Side effects 6 Special instructions 7 Drug interactions 8 Terms and conditions of storage Prices in online pharmacies: from 27 rubles Buy Cinnarizine is a piperazine derivative with antihistaminic and calcium channel-blocking activities It inhibits calcium translocation across the vestibular sensory cells in the ampullae and maintains endolymph flow by preventing constriction of the stria vascularis Apr 25, 2017 · Cinnarizine is a well-established anti-vertigo drug initially synthesized as an anti-histamine [] It is the mainstay therapy for vestibular disorders [], approved for nausea, vomiting, motion sickness, vertigo and tinnitus associated with Ménière’s disease and other middle ear disorders, as a nootropic drug (memory and cognitive function enhancer) and as adjunct therapy for peripheral Clinical Drug Investigation Article Efficacy and Safety of a Fixed Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg vs Betahistine Dihydrochloride 16 mg in Patients with Peripheral Vestibular Vertigo: A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Non-inferiority Clinical Trial Original Research Article See full list on drugs com Is cinnarizine an anti-histamine? go drugbank com drugs DB00568Return to Index • Page last modified: August 22, 2020 Cinnarizine (not available in USA) Cinnarizine, not available in the US or Canada, is mainly marketed elsewhere as a H1 antihistamine It, like betahistine, was originally developed by Janssen Pharmaceutica Why is cinnarizine considered a nootropic drug? Chemical Names trans-1-cinnamyl-4-diphenylmetylpiperazine (WHO) 1-Cinnamyl-4- (diphenylmetyl)piperazine (USAN) Piperazine, 1- (diphenylmetyl)-4- (3-phenyl-2-propenyl)- (USAN) Foreign Names Cinnarizinum (Latin) Cinnarizin (German) Cinnarizine (French) Cinarizina (Spanish) Generic Names Cinnarizina (OS: DCIT) Cinnarizine (OS: DCF, USAN, JAN, BAN)link springer com article 10 1007 s12070-017-1120-7People also ask What Cinnarizine tablets contain: • The active ingredient is cinnarizine 15 mg • The other ingredients are lactose, starch, povidone, isopropyl alcohol, magnesium stearate, pregelatinised starch and colloidal anhydrous silica (inactive ingredients) What Cinnarizine tablets look like and contents of the pack: abchealthonline com 6587665-cinnarizine-instructions-for-use-indications- --- pediatriconcall com drugs cinnarizine 420What are the ingredients in cinnarizine? dizziness-and-balance com treatment drug cinnarizine htmlonlinelibrary wiley com doi 10 1111 papr 1316425 Citations Explore all metrics Abstract Cinnarizine, is approved for nausea, vomiting, motion sickness, inner ear disorders and is considered as first-line pharmacotherapy for management of vertigo It acts by anti-vasoconstrictor activity, reducing blood viscosity and reducing nystagmus in labyrinth Cinnarizine can be considered a safe and effective medication for migraine prophylaxis However, the relatively small sample size made reaching a definite conclusion impossible Therefore, a higher number of randomized controlled trials are recommended to be taken place to clarify the situation further CONFLICT OF INTEREST None Open Research N O P Q R S T U V W X Y Z Cinnarizine Mechanism : Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels Cinnarizine has also been implicated in binding to dopamine D2 receptors, histamine H1 receptors, and muscarinic acetylcholine receptors Indication :Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus Important Information Before taking the drug How to use the drug Keep in mind while taking Side effects Brands List of brands containing cinnarizine This page contains list of brands of authorized pharmaceutical specialties of the active principle cinnarizine in the countries listed below:Aug 22, 2020 · Cinnarizine (not available in USA ) Cinnarizine , not available in the US or Canada, is mainly marketed elsewhere as a H1 antihistamine It, like betahistine, was originally developed by Janssen Pharmaceutica Cinnarizine also antagonizes noradrenaline, nicotine and angiotension, and as well it is a calcium chann
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